Effect of aramine on the survival of dogs subjected to hemorrhagic hypotension.

One group of 19 control dogs and other group of 20 "treated" dogs were bled into hemorrhagic hypotension after Nembutal anesthesia and their arterial pressures controlled at 40 mm. Hg for an average period of one hour and fifteen minutes. Neither group had further blood depletion, or replacement, for an additional 1 hour and 39 minutes, but the treated group received Aramine. Reinfusion was performed after an oligemic period totaling 2 hours and 54 minutes. Of the clogs in the control group, 10.5 per cent survived; 50 per cent of the treated dogs survived.